@article{Lifu Wang_Guilin Tang_L. Jeffrey Medeiros_Jie Xu_Wenting Huang_C. Cameron Yin_Michael Wang_Preetesh Jain_Pei Lin_Shaoying Li_2021, place={Pavia, Italy}, title={<i>MYC</i> rearrangement but not extra <i>MYC</i> copies is an independent prognostic factor in patients with mantle cell lymphoma}, volume={106}, url={https://haematologica.org/article/view/9709}, DOI={10.3324/haematol.2019.243071}, abstractNote={<p>Mantle cell lymphoma (MCL) with MYC rearrangement (MYC-R) is rare and little is known about the importance of MYC extra copies (EC) in the absence of MYC-R in MCL patients. This study includes 88 MCL patients with MYC tested by fluorescence in situ hybridization and/or conventional cytogenetics, including 27 with MYC-R, 21 with MYC-EC, and 40 with normal (NL) MYC. MCL patients with MYC-R more often had blastoid/pleomorphic morphology; a higher frequency of CD10, MYC, and simultaneous MYC and BCL2 expression; a higher level of MYC; and a higher Ki67 proliferation rate (p&lt;0.05) than those without MYC-R. Although patients with MYC-R more frequently received aggressive chemotherapy (p=0.001), their overall survival (OS) was significantly shorter than those without MYC-R. Compared with patients with MYC/BCL2 double hit lymphoma (DHL), patients with MYC-R MCL had a similar OS but more commonly had bone marrow involvement, stage 4 disease, and a different immunophenotype. MCL patients with MYC-EC showed an OS intermediate between those with MYC-R and MYC-NL, either all or only blastoid/pleomorphic MCL patients included. Multivariate analysis showed that MYC-R, but not MYC-EC, had an independent and negative impact on OS. In conclusion, MYC-R but not MYC-EC showed a higher MYC expression and is an adverse prognostic factor for MCL patients. Although the OS of MCL patients with MYC-R is similar to that of MYC/BCL2 DHL patients, these groups have different clinicopathologic features supporting the retention of MCL with MYC-R in the category of MCL, as recommended in the revised World Health Organization classification.</p&gt;}, number={5}, journal={Haematologica}, author={Lifu Wang and Guilin Tang and L. Jeffrey Medeiros and Jie Xu and Wenting Huang and C. Cameron Yin and Michael Wang and Preetesh Jain and Pei Lin and Shaoying Li}, year={2021}, month={Apr.}, pages={1381-1389} }