@article{Xavier Poiré_Myriam Labopin_Emmanuelle Polge_Edouard Forcade_Arnold Ganser_Liisa Volin_Mauricette Michallet_Didier Blaise_Ibrahim Yakoub-Agha_Johan Maertens_Carlos Richard Espiga_Jan Cornelissen_Jürgen Finke_Mohamad Mohty_Jordi Esteve_Arnon Nagler_2020, place={Pavia, Italy}, title={Allogeneic stem cell transplantation using HLA-matched donors for acute myeloid leukemia with deletion 5q or monosomy 5: a study from the Acute Leukemia Working Party of the EBMT}, volume={105}, url={https://haematologica.org/article/view/9526}, DOI={10.3324/haematol.2019.216168}, abstractNote={Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation. However, -5/5q- is frequently associated with other high-risk cytogenetic aberrations such as complex karyotype, monosomal karyotype, monosomy 7 (-7), or 17p abnormalities (abn (17p)), the significance of which is unknown. In order to address this question, we studied adult patients with AML harboring -5/5q- having their first allogeneic transplantation between 2000 and 2015. Five hundred and one patients with -5/5q- have been analyzed. Three hundred and thirty-eight patients (67%) were in first remission and 142 (28%) had an active disease at time of allogeneic transplantation. The 2-year probabilities of overall survival and leukemia-free survival were 27% and 20%, respectively. The 2-year probability of treatment-related mortality was 20%. We identified four different cytogenetic groups according to additional abnormalities with prognostic impact: -5/5q- without complex karyotype, monosomal karyotype or abn(17p), -5/5q- within a complex karyotype, -5/5q- within a monosomal karyotype and the combination of -5/5q- with abn(17p). In multivariate analysis, factors associated with worse overall survival and leukemia-free survival across the four groups were active disease, age, monosomal karyotype, and abn(17p). The presence of -5/5q- without monosomal karyotype or abn(17p) was associated with a significantly better survival rate while -5/5q- in conjunction with monosomal karyotype or abn(17p) translated into a worse outcome. The patients harboring the combination of -5/5q- with abn(17p) showed very limited benefit from allogeneic transplantation.}, number={2}, journal={Haematologica}, author={Xavier Poiré and Myriam Labopin and Emmanuelle Polge and Edouard Forcade and Arnold Ganser and Liisa Volin and Mauricette Michallet and Didier Blaise and Ibrahim Yakoub-Agha and Johan Maertens and Carlos Richard Espiga and Jan Cornelissen and Jürgen Finke and Mohamad Mohty and Jordi Esteve and Arnon Nagler}, year={2020}, month={Jan.}, pages={414-423} }