@article{Luxiang Wang_Shuo Gao_Haihong Wang_Chang Xue_Xiaohui Liu_Hao Yuan_Zixuan Wang_Saijuan Chen_Zhu Chen_Hugues de Thé_Yiyue Zhang_Wenqing Zhang_Jun Zhu_Jun Zhou_2020, place={Pavia, Italy}, title={Interferon regulatory factor 2 binding protein 2b regulates neutrophil versus macrophage fate during zebrafish definitive myelopoiesis}, volume={105}, url={https://haematologica.org/article/view/9517}, DOI={10.3324/haematol.2019.217596}, abstractNote={Aproper choice of neutrophil-macrophage progenitor cell fate is essential for the generation of adequate myeloid subpopulations during embryonic development and in adulthood. The network governing neutrophil-macrophage progenitor cell fate has several key determinants, such as myeloid master regulators CCAAT enhancer binding protein alpha (C/EBPα) and spleen focus forming virus proviral integration oncogene (PU.1). Nevertheless, more regulators remain to be identified and characterized. To ensure balanced commitment of neutrophil-macrophage progenitors toward each lineage, the interplay among these determinants is not only synergistic, but also antagonistic. Depletion of interferon regulatory factor 2 binding protein 2b (Irf2bp2b), a well-known negative transcription regulator, results in a bias in neutrophil-macrophage progenitor cell fate in favor of macrophages at the expense of neutrophils during the stage of definitive myelopoiesis in zebrafish embryos. Mechanistic studies indicate that Irf2bp2b acts as a downstream target of C/EBPα, repressing PU.1 expression, and that SUMOylation confers the repressive function of Irf2bp2b. Thus, Irf2bp2b is a novel determinant in the choice of fate of neutrophil-macrophage progenitor cells.}, number={2}, journal={Haematologica}, author={Luxiang Wang and Shuo Gao and Haihong Wang and Chang Xue and Xiaohui Liu and Hao Yuan and Zixuan Wang and Saijuan Chen and Zhu Chen and Hugues de Thé and Yiyue Zhang and Wenqing Zhang and Jun Zhu and Jun Zhou}, year={2020}, month={Jan.}, pages={325-337} }