@article{Marius Bill_Deedra Nicolet_Jessica Kohlschmidt_Christopher J. Walker_Krzysztof Mrózek_Ann-Kathrin Eisfeld_Dimitrios Papaioannou_Xiaoqing Rong-Mullins_Zachary Brannan_Jonathan E. Kolitz_Bayard L. Powell_Kellie J. Archer_Adrienne M. Dorrance_Andrew J. Carroll_Richard M. Stone_John C. Byrd_Ramiro Garzon_Clara D. Bloomfield_2020, place={Pavia, Italy}, title={Mutations associated with a 17-gene leukemia stem cell score and the score’s prognostic relevance in the context of the European LeukemiaNet classification of acute myeloid leukemia}, volume={105}, url={https://haematologica.org/article/view/9290}, DOI={10.3324/haematol.2019.225003}, abstractNote={Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular markers associated with stemness could lead to better clinical management and improve patients’ outcomes. We applied a previously described 17-gene expression score comprising genes differently expressed between LSC and leukemic bulk blasts, for 934 adult patients with <em>de novo</em> AML, and studied associations of the 17-gene LSC score with clinical data and mutation status of 81 genes recurrently mutated in cancer and leukemia. We found that patients with a high 17-gene score were older and had more mutations. The 17-gene score was found to have a prognostic impact in both younger (aged &lt;60 years) and older (aged ≥60 years) patients with AML. We also analyzed the 17-gene LSC score in the context of the 2017 European LeukemiaNet genetic-risk classification and found that for younger patients the score refined the classification, and identified patients currently classified in the European LeukemiaNet Favorable-risk category who had a worse outcome.}, number={3}, journal={Haematologica}, author={Marius Bill and Deedra Nicolet and Jessica Kohlschmidt and Christopher J. Walker and Krzysztof Mrózek and Ann-Kathrin Eisfeld and Dimitrios Papaioannou and Xiaoqing Rong-Mullins and Zachary Brannan and Jonathan E. Kolitz and Bayard L. Powell and Kellie J. Archer and Adrienne M. Dorrance and Andrew J. Carroll and Richard M. Stone and John C. Byrd and Ramiro Garzon and Clara D. Bloomfield}, year={2020}, month={Mar.}, pages={721-729} }