@article{Giorgia Battipaglia_Florent Malard_Marie Therèse Rubio_Annalisa Ruggeri_Anne Claire Mamez_Eolia Brissot_Federica Giannotti_Remy Dulery_Anne Christine Joly_Minh Tam Baylatry_Marie Jeanne Kossmann_Jacques Tankovic_Laurent Beaugerie_Harry Sokol_Mohamad Mohty_2019, place={Pavia, Italy}, title={Fecal microbiota transplantation before or after allogeneic hematopoietic transplantation in patients with hematologic malignancies carrying multidrug-resistance bacteria}, volume={104}, url={https://haematologica.org/article/view/9017}, DOI={10.3324/haematol.2018.198549}, abstractNote={Fecal microbiota transplantation is an effective treatment in recurrent <em>Clostridium difficile</em> infection. Promising results to eradicate multidrug-resistant bacteria have also been reported with this procedure, but there are safety concerns in immunocompromised patients. We report results in ten adult patients colonized with multidrug-resistant bacteria, undergoing fecal microbiota transplantation before (n=4) or after (n=6) allogeneic hematopoietic stem cell transplantation for hematologic malignancies. were obtained from healthy related or unrelated donors. Fecal material was delivered either by enema or <em>via</em> nasogastric tube. Patients were colonized or had infections from either carbapenemase-producing bacteria (n=8) or vancomycin-resistant enterococci (n=2). Median age at fecal microbiota transplantation was 48 (range, 16-64) years. Three patients needed a second transplant from the same donor due to initial failure of the procedure. With a median follow up of 13 (range, 4-40) months, decolonization was achieved in seven of ten patients. In all patients, fecal micro-biota transplantation was safe: one patient presented with constipation during the first five days after FMT and two patients had grade I diarrhea. One case of gut grade III acute graft-<em>versus</em&gt;-host disease occurred after fecal microbiota transplantation. In patients carrying or infected by multidrug-resistant bacteria, fecal microbiota transplantation is an effective and safe decolonization strategy, even in those with hematologic malignancies undergoing hematopoietic stem cell transplantation.}, number={8}, journal={Haematologica}, author={Giorgia Battipaglia and Florent Malard and Marie Therèse Rubio and Annalisa Ruggeri and Anne Claire Mamez and Eolia Brissot and Federica Giannotti and Remy Dulery and Anne Christine Joly and Minh Tam Baylatry and Marie Jeanne Kossmann and Jacques Tankovic and Laurent Beaugerie and Harry Sokol and Mohamad Mohty}, year={2019}, month={Jul.}, pages={1682-1688} }