@article{E Zuffa_N Vianelli_G Martinelli_P Tazzari_M Cavo_S Tura_1996, place={Pavia, Italy}, title={Autoimmune mediated thrombocytopenia associated with the use of interferon-alpha in chronic myeloid leukemia}, volume={81}, url={https://haematologica.org/article/view/839}, DOI={10.3324/%x}, abstractNote={We report on two patients with Ph+ chronic myeloid leukemia (CML) in chronic phase who developed severe thrombocytopenia during treatment with interferon-alpha 2A (IFN-alpha 2A). In both cases, we detected the presence of platelet-associated antibodies (PAIg) by autoimmune flow cytometry. We postulated an immune mediated platelet destruction mechanism; corticosteroid therapy was employed and interferon therapy was withdrawn, resulting in an increase in platelet count and a reduction of PAIg. Our observation reports the detection of PAIg associated with IFN-alpha 2A therapy in CML and suggests that this immunomodulant drug could induce thrombocytopenia through a mechanism other than antiproliferation.}, number={6}, journal={Haematologica}, author={E Zuffa and N Vianelli and G Martinelli and P Tazzari and M Cavo and S Tura}, year={1996}, month={Nov.}, pages={533-535} }