@article{Natasha Kekre_Ying Zhang_Mei-Jie Zhang_Jeanette Carreras_Parvez Ahmed_Paolo Anderlini_Elias Hallack Atta_Mouhab Ayas_Jaap Jan Boelens_Carmem Bonfim_H. Joachim Deeg_Neena Kapoor_Jong-Wook Lee_Ryotaro Nakamura_Michael A. Pulsipher_Mary Eapen_Joseph H. Antin_2017, place={Pavia, Italy}, title={Effect of antithymocyte globulin source on outcomes of bone marrow transplantation for severe aplastic anemia}, volume={102}, url={https://haematologica.org/article/view/8136}, DOI={10.3324/haematol.2017.164459}, abstractNote={For treatment of severe aplastic anemia, immunosuppressive therapy with horse antithymocyte globulin results in superior response and survival compared with rabbit antithymocyte globulin. This relative benefit may be different in the setting of transplantation as rabbit antithymocyte globulin results in more profound immunosuppression. We analyzed 833 severe aplastic anemia transplants between 2008 and 2013 using human leukocyte antigen (HLA)-matched siblings (n=546) or unrelated donors (n=287) who received antithymocyte globulin as part of their conditioning regimen and bone marrow graft. There were no differences in hematopoietic recovery by type of antithymocyte globulin. Among recipients of HLA-matched sibling transplants, day 100 incidence of acute (17% <em>versus</em> 6%, <em>P</em><0.001) and chronic (20% <em>versus</em> 9%, <em>P</em><0.001) graft-<em>versus</em>-host disease were higher with horse compared to rabbit antithymocyte globulin. There were no differences in 3-year overall survival, 87% and 92%, <em>P</em>=0.76, respectively. Among recipients of unrelated donor transplants, acute graft-<em>versus</em>-host disease was also higher with horse compared to rabbit antithymocyte globulin (42% <em>versus</em> 23%, <em>P</em><0.001) but not chronic graft-<em>versus</em>-host disease (38% <em>versus</em> 32%, <em>P</em>=0.35). Survival was lower with horse antithymocyte globulin after unrelated donor transplantation, 75% <em>versus</em> 83%, <em>P</em&gt;=0.02. These data support the use of rabbit antithymocyte globulin for bone marrow transplant conditioning for severe aplastic anemia.}, number={7}, journal={Haematologica}, author={Natasha Kekre and Ying Zhang and Mei-Jie Zhang and Jeanette Carreras and Parvez Ahmed and Paolo Anderlini and Elias Hallack Atta and Mouhab Ayas and Jaap Jan Boelens and Carmem Bonfim and H. Joachim Deeg and Neena Kapoor and Jong-Wook Lee and Ryotaro Nakamura and Michael A. Pulsipher and Mary Eapen and Joseph H. Antin}, year={2017}, month={Jun.}, pages={1291-1298} }