@article{Natalia Rivkin_Elik Chapnik_Alexander Mildner_Gregory Barshtein_Ziv Porat_Elena Kartvelishvily_Tali Dadosh_Yehudit Birger_Gail Amir_Saul Yedgar_Shai Izraeli_Steffen Jung_Eran Hornstein_2017, place={Pavia, Italy}, title={Erythrocyte survival is controlled by microRNA-142}, volume={102}, url={https://haematologica.org/article/view/8033}, DOI={10.3324/haematol.2016.156109}, abstractNote={Hematopoietic–specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-function allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for the normal metabolism of reactive oxygen species, and for overall lifespan. microRNA-142 further controls ACTIN filament homeostasis and membrane skeleton organization. The analyses presented reveal previously unappreciated functions of microRNA-142 and contribute to an emerging view of small RNAs as key players in erythropoiesis. Finally, the work herein demonstrates how a housekeeping network of cytoskeletal regulators can be reshaped by a single micro-RNA denominator in a cell type specific manner.}, number={4}, journal={Haematologica}, author={Natalia Rivkin and Elik Chapnik and Alexander Mildner and Gregory Barshtein and Ziv Porat and Elena Kartvelishvily and Tali Dadosh and Yehudit Birger and Gail Amir and Saul Yedgar and Shai Izraeli and Steffen Jung and Eran Hornstein}, year={2017}, month={Mar.}, pages={676-685} }