@article{Suzanna M. van Walraven_Anneke Brand_Jack N.A. Bakker_Martin B.A. Heemskerk_Suzan Nillesen_Marc B. Bierings_Laura B. Bungener_Bouke G. Hepkema_Arjan Lankester_Arnold van der Meer_Kees Sintnicolaas_Judith A.E. Somers_Eric Spierings_Marcel G.J. Tilanus_Christien E.M. Voorter_Jan J. Cornelissen_Machteld Oudshoorn_2016, place={Pavia, Italy}, title={The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent}, volume={102}, url={https://haematologica.org/article/view/7936}, DOI={10.3324/haematol.2016.145730}, abstractNote={Between 2001 and 2012, the number of unrelated donors registered worldwide increased from 7 to 21 million, and the number of public cord blood units increased to over 500,000. We addressed the question of whether this expansion resulted in higher percentages of patients reaching transplantation. Unrelated donor searches were evaluated for 3,124 eligible patients in the Netherlands in two cohorts (2001–2006, n=995; 2007–2012, n=2129), comparing results for patients of Northwestern European and non-Northwestern European origin. Endpoints were ‘donor found’ and ‘transplantation reached’. The substantial growth of the donor inventory over the period studied did not increase the median number of potential unrelated donors (n=7) for non-Northwestern European patients, but almost doubled the number for Northwestern European patients from 42 to 71. Before and after 2007, an unrelated donor or cord blood was identified for 91% and 95%, respectively, of Northwestern European patients and for 65% and 82% of non-Northwestern European patients (<em>P</em><0.0001). Non-Northwestern European patients more often needed a cord blood transplant. The degree of HLA matching was significantly lower for non-Northwestern European patients (<em>P</em><0.0006). The time needed to identify a donor decreased for both populations. The percentage of Northwestern European patients reaching transplantation increased from 77% to 83% and for non-Northwestern European patients from 57% to 72% (<em>P</em&gt;=0.0003). The increase of the global inventory resulted in more transplants for patients lacking a family donor, although the quality and quantity of (potential) haematopoietic cell grafts for patients of a non-Northwestern European descent remained inferior, indicating the need for adaptation of recruitment.}, number={1}, journal={Haematologica}, author={Suzanna M. van Walraven and Anneke Brand and Jack N.A. Bakker and Martin B.A. Heemskerk and Suzan Nillesen and Marc B. Bierings and Laura B. Bungener and Bouke G. Hepkema and Arjan Lankester and Arnold van der Meer and Kees Sintnicolaas and Judith A.E. Somers and Eric Spierings and Marcel G.J. Tilanus and Christien E.M. Voorter and Jan J. Cornelissen and Machteld Oudshoorn}, year={2016}, month={Dec.}, pages={176-183} }