@article{Annalisa Paviglianiti_Erick Xavier_Annalisa Ruggeri_Patrice Ceballos_Eric Deconinck_Jan J. Cornelissen_Stephanie Nguyen-Quoc_Natacha Maillard_Guillermo Sanz_Pierre-Simon Rohrlich_Laurent Garderet_Fernanda Volt_Vanderson Rocha_Nicolaus Kroeger_Eliane Gluckman_Nathalie Fegueux_Mohamad Mohty_2016, place={Pavia, Italy}, title={Outcomes of unrelated cord blood transplantation in patients with multiple myeloma: a survey on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobiology Working Party, and the Chronic Leukemia Working Party of the EBMT}, volume={101}, url={https://haematologica.org/article/view/7825}, DOI={10.3324/haematol.2015.138917}, abstractNote={Although allogeneic stem cell transplantation is not a standard therapy for multiple myeloma, some patients can benefit from this intense therapy. There are few reports on outcomes after umbilical cord blood transplantation in multiple myeloma, and investigation of this procedure is warranted. We retrospectively analyzed 95 patients, 85 with multiple myeloma and 10 with plasma cell leukemia, receiving single or double umbilical cord blood transplantation from 2001 to 2013. Median follow up was 41 months. The majority of patients received a reduced intensity conditioning. The cumulative incidence of neutrophil engraftment was 97%±3% at 60 days, and that of 100-day acute graft-<em>versus</em>-host disease grade II-IV was 41%±5%. Chronic graft-<em>versus</em>-host disease at two years was 22%±4%. Relapse and non-relapse mortality was 47%±5% and 29%±5% at three years, respectively. Three-year progression-free survival and overall survival were 24%±5% and 40%±5%, respectively. Anti-thymocyte globulin was associated with decreased incidence of acute graft-<em>versus</em&gt;-host disease, higher non-relapse mortality, decreased overall and progression-free survival. Patients with high cytogenetic risk had higher relapse, and worse overall and progression-free survival. In conclusion, umbilical cord blood transplantation is feasible for multiple myeloma patients.}, number={9}, journal={Haematologica}, author={Annalisa Paviglianiti and Erick Xavier and Annalisa Ruggeri and Patrice Ceballos and Eric Deconinck and Jan J. Cornelissen and Stephanie Nguyen-Quoc and Natacha Maillard and Guillermo Sanz and Pierre-Simon Rohrlich and Laurent Garderet and Fernanda Volt and Vanderson Rocha and Nicolaus Kroeger and Eliane Gluckman and Nathalie Fegueux and Mohamad Mohty}, year={2016}, month={Aug.}, pages={1120-1127} }