@article{Cornelia Zeidler_Ulrike A.H. Grote_Anna Nickel_Beate Brand_Göran Carlsson_Emília Cortesão_Carlo Dufour_Caroline Duhem_Gundula Notheis_Helen A. Papadaki_Hannah Tamary_Geir E. Tjønnfjord_Fabio Tucci_Jan Van Droogenbroeck_Christiane Vermylen_Jaroslava Voglova_Blanca Xicoy_Karl Welte_2014, place={Pavia, Italy}, title={Outcome and management of pregnancies in severe chronic neutropenia patients by the European Branch of the Severe Chronic Neutropenia International Registry}, volume={99}, url={https://haematologica.org/article/view/7121}, DOI={10.3324/haematol.2013.099101}, abstractNote={Long-term granulocyte-colony stimulating factor treatment has been shown to be safe and effective in severe chronic neutropenia patients. However, data on its use during pregnancy are limited. To address this issue, we analyzed all pregnancies reported to the European branch of the Severe Chronic Neutropenia International Registry since 1994. A total of 38 pregnancies in 21 women with chronic neutropenia (16 pregnancies in 10 women with congenital, 10 in 6 women with cyclic, 12 in 5 women with idiopathic neutropenia) were reported. Granulocyte-colony stimulating factor was administered throughout pregnancy in 16 women and for at least one trimester in a further 5 women. No major differences were seen between treated and untreated women with respect to pregnancy outcome, newborn complications and infections. In addition, we evaluated the genetic transmission of known or suspected genetic defects in 16 mothers having 22 newborns as well as in 8 men fathering 15 children. As a proof of inheritance, neutropenia was passed on to the newborn in 58% from female and in 62% from male patients with <em>ELANE</em&gt; mutations, but also to some newborns from parents with unknown gene mutation. Based on our results, granulocyte-colony stimulating factor therapy has been shown to be safe for mothers throughout pregnancies and for newborns without any signs of teratogenicity. With an increasing number of adult patients, genetic counseling prior to conception and supportive care of mothers during pregnancy are crucial. The acceptance of having affected children may reflect the high quality of life obtained due to this treatment.}, number={8}, journal={Haematologica}, author={Cornelia Zeidler and Ulrike A.H. Grote and Anna Nickel and Beate Brand and Göran Carlsson and Emília Cortesão and Carlo Dufour and Caroline Duhem and Gundula Notheis and Helen A. Papadaki and Hannah Tamary and Geir E. Tjønnfjord and Fabio Tucci and Jan Van Droogenbroeck and Christiane Vermylen and Jaroslava Voglova and Blanca Xicoy and Karl Welte}, year={2014}, month={Jul.}, pages={1395-1402} }