@article{José Luis Piñana_Jaime Sanz_Alessandra Picardi_Christelle Ferrá_Rodrigo Martino_Pere Barba_Marta Gonzalez-Vicent_María Jesús Pascual_Carmen Martín_Amparo Verdeguer_Cristina Diaz de Heredia_Pau Montesinos_José-María Ribera_Miguel Sanz_William Arcese_Guillermo Sanz_2014, place={Pavia, Italy}, title={Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia}, volume={99}, url={https://haematologica.org/article/view/6940}, DOI={10.3324/haematol.2013.091009}, abstractNote={There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) in second complete remission and six (14%) in third or subsequent response. The cumulative incidence of myeloid engraftment was 96% at a median time of 20 days and significantly better for patients receiving higher doses of CD34<sup>+</sup> cells. The incidence of acute grade II–IV graft-<em>versus</em>-host disease was 31%, while that of overall chronic graft-<em>versus</em>-host disease was 53%. Treatment-related mortality was 17% at day +100 and 31% at 5 years. The 5-year relapse, event-free survival and overall survival rates were 31%, 36% and 44%, respectively. Although the event-free and overall survival rates in patients without <em>BCR/ABL</em> transcripts detectable at time of transplant were better than those in whom <em>BCR/ABL</em> transcripts were detected (46% <em>versus</em> 24% and 60% <em>versus</em> 30%, respectively) these differences were not statistically significant in the univariate analysis (<em>P</em&gt;=0.07). These results demonstrate that umbilical cord blood transplantation from unrelated donors can be a curative treatment for a substantial number of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.}, number={2}, journal={Haematologica}, author={José Luis Piñana and Jaime Sanz and Alessandra Picardi and Christelle Ferrá and Rodrigo Martino and Pere Barba and Marta Gonzalez-Vicent and María Jesús Pascual and Carmen Martín and Amparo Verdeguer and Cristina Diaz de Heredia and Pau Montesinos and José-María Ribera and Miguel Sanz and William Arcese and Guillermo Sanz}, year={2014}, month={Feb.}, pages={378-384} }