@article{Sita R. Dewamitta_Megan R. Russell_Harshal Nandurkar_Carl R. Walkley_2013, place={Pavia, Italy}, title={Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment}, volume={98}, url={https://haematologica.org/article/view/6654}, DOI={10.3324/haematol.2012.078709}, abstractNote={Erythropoiesis stimulating agents are widely used for the treatment of anemia. Recently, we reported erythroid expansion with impaired B lymphopoiesis and loss of trabecular bone in C57BL/6 mice following ten days of treatment with low-dose short acting recombinant human erythropoietin. We have assessed erythropoietin against longer-acting darbepoietin-alfa at a comparable erythroid stimulatory dosage regime. Darbepoietin-alfa and erythropoietin induced similar <em>in vivo</em> erythropoietic expansion. Both agents induced an expansion of the colony-forming unit-erythroid populations. However, unlike erythropoietin, darbepoietin-alfa did not impair bone marrow B lymphopoiesis. Strikingly the bone loss observed with erythropoietin was not apparent following darbepoietin-alfa treatment. This analysis demonstrates that whilst darbepoietin-alfa has similar <em>in vivo</em&gt; erythropoietic potency to erythropoietin, it preserves the bone marrow microenvironment. Thus erythropoietin and darbepoietin-alfa manifest different action showing that erythropoiesis stimulating agents have differential non-erythroid effects dependent on their duration of action.}, number={5}, journal={Haematologica}, author={Sita R. Dewamitta and Megan R. Russell and Harshal Nandurkar and Carl R. Walkley}, year={2013}, month={Apr.}, pages={686-690} }