@article{Bruno C. Medeiros_Megan Othus_Elihu H. Estey_Min Fang_Frederick R. Appelbaum_2012, place={Pavia, Italy}, title={Impact of body-mass index on the outcome of adult patients with acute myeloid leukemia}, volume={97}, url={https://haematologica.org/article/view/6411}, DOI={10.3324/haematol.2011.056390}, abstractNote={<strong>Background</strong> Obesity increases the risk of treatment-related complications and reduces survival in children with acute myeloid leukemia. Little is known about the impact of obesity on the outcome of adult patients with acute myeloid leukemia.<strong>Design and Methods</strong> We compared the baseline characteristics and effect on treatment and survival in 1,974 previously untreated adult patients with acute myeloid leukemia undergoing treatment, according to international classification of body-mass index.<strong>Results</strong> The median body-mass index was 26.7 (15.5–61) and 63% of patients were overweight/obese. After adjustment for other confounders, such as age, gender, performance status, karyotype, white blood cell, platelet and peripheral blast counts, obese patients had better complete remission rates (<em>P</em>=0.0046), lower rates of resistant disease (<em>P</em>=0.038) but similar rates of survival and severe adverse events.<strong>Conclusions</strong&gt; In the treatment of acute myeloid leukemia in adults, obesity was associated with increased response rates and no apparent increase in toxicity. Obesity should not, therefore, be a criterion for excluding patients from aggressive therapy.}, number={9}, journal={Haematologica}, author={Bruno C. Medeiros and Megan Othus and Elihu H. Estey and Min Fang and Frederick R. Appelbaum}, year={2012}, month={Sep.}, pages={1401-1404} }