@article{Esperanza Such_José Cervera_Evangelos Terpos_José V Bagán_Amparo Avaria_Inés Gómez_María Margaix_Mariam Ibañez_Irene Luna_Lourdes Cordón_Mónica Roig_Miguel A. Sanz_Meletios A. Dimopoulos_Javier de la Rubia_2011, place={Pavia, Italy}, title={CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma}, volume={96}, url={https://haematologica.org/article/view/6106}, DOI={10.3324/haematol.2011.042572}, abstractNote={Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (<em>CYP2C8</em>) polymorphism <em>rs1934951</em> was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma patients treated with bisphosphonates. The aim of this study was to validate the frequency of SNP <em>rs193451</em&gt; in 79 patients with multiple myeloma. In 9 (22%) patients developing osteonecrosis of the jaw, a heterozygous genotype was found, in contrast with those who did not develop osteonecrosis of the jaw (n=4, 11%) or healthy individuals (n=6, 13%). We found no differences in the cumulative risk of developing osteonecrosis of the jaw between patients homozygous and heterozygous for the major allele. We were unable to confirm a significant association between this polymorphism and the risk of developing osteonecrosis of the jaw.}, number={10}, journal={Haematologica}, author={Esperanza Such and José Cervera and Evangelos Terpos and José V Bagán and Amparo Avaria and Inés Gómez and María Margaix and Mariam Ibañez and Irene Luna and Lourdes Cordón and Mónica Roig and Miguel A. Sanz and Meletios A. Dimopoulos and Javier de la Rubia}, year={2011}, month={Oct.}, pages={1557-1559} }