@article{Sophie de Guibert_Régis Peffault de Latour_Nathalie Varoqueaux_Hélène Labussière_Bernard Rio_Dominique Jaulmes_Jean-Richard Eveillard_Stéphanie Dulucq_Anne-Marie Stoppa_Didier Bouscary_François Girodon_Bernard Bonnotte_Djamila Laskri_Gérard Socié_Thierry Lamy_2011, place={Pavia, Italy}, title={Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience}, volume={96}, url={https://haematologica.org/article/view/6064}, DOI={10.3324/haematol.2010.037531}, abstractNote={<strong>Background</strong> Pregnancy in women with paroxysmal nocturnal hemoglobinuria is rare, with few reports on maternal and fetal mortality rates.<strong>Design and Methods</strong> A specific questionnaire designed to solicit data on pregnancies in women with paroxysmal nocturnal hemoglobinuria was sent to all members of the French Society of Hematology in January 2008.<strong>Results</strong> We identified 27 pregnancies in 22 women at 10 French Society of Hematology centers between 1978 and 2008. The median age was 21.5 years at diagnosis of paroxysmal nocturnal hemoglobinuria and 27 years at pregnancy. None of these women had received eculizumab during their pregnancy. Maternal complications, consisting mostly of cytopenias requiring transfusions, occurred in 95% of cases. Two cases of severe aplastic anemia (<em>de novo</em> in one case and relapse in the other) were recorded. No thrombotic events occurred during pregnancy, whereas 4 postpartum thromboses (16%) were recorded, 2 of which were fatal (maternal mortality rate 8%). Most patients received antithrombotic prophylaxis during pregnancy and postpartum (n=16; 64%). Delivery was preterm in 29% of cases, and birth weight was less than 3 kg in 53% of cases. Fetal mortality rate was 4%.<strong>Conclusions</strong&gt; Pregnancy during paroxysmal nocturnal hemoglobinuria is associated with increased maternal and fetal mortality rates (8% and 4%, respectively, in this series). Maternal mortality is related to postpartum thromboses. Prophylactic anticoagulation is recommended during pregnancy and for six weeks postpartum.}, number={9}, journal={Haematologica}, author={Sophie de Guibert and Régis Peffault de Latour and Nathalie Varoqueaux and Hélène Labussière and Bernard Rio and Dominique Jaulmes and Jean-Richard Eveillard and Stéphanie Dulucq and Anne-Marie Stoppa and Didier Bouscary and François Girodon and Bernard Bonnotte and Djamila Laskri and Gérard Socié and Thierry Lamy}, year={2011}, month={Aug.}, pages={1276-1283} }