@article{Olivier Kosmider_Eric Delabesse_Véronique Mansat-De Mas_Pascale Cornillet-Lefebvre_Odile Blanchet_Alain Delmer_Christian Recher_Sophie Raynaud_Didier Bouscary_Franck Viguié_Catherine Lacombe_Olivier A. Bernard_Norbert Ifrah_François Dreyfus_Michaëla Fontenay_2011, place={Pavia, Italy}, title={TET2 mutations in secondary acute myeloid leukemias: a French retrospective study}, volume={96}, url={https://haematologica.org/article/view/6015}, DOI={10.3324/haematol.2011.040840}, abstractNote={<em>Ten-eleven translocation 2 (TET2)</em> mutations have been involved in myeloid malignancies. This retrospective study aims at evaluating the frequency and impact of <em>TET2</em> mutations in 247 secondary acute myeloid leukemia cases referred to as myelodysplasia-related changes (n=201) or therapy-related (n=46) leukemias. Mutation of at least one copy of the <em>TET2</em> gene was detected in 49 of 247 (19.8%) patients who presented with older age, higher hemoglobin level, higher neutrophil and monocyte counts, and lower platelet count. <em>TET2</em> mutations were significantly less frequent in therapy-related (8.7%) than myelodysplasia-related changes (22.3%; <em>P</em>=0.035) leukemias and strongly associated with normal karyotype (<em>P</em><0.001). <em>TET2</em> mutations did not significantly associate with <em>NPM1</em>, <em>FLT3-ITD</em> or <em>FLT3-D835</em>, <em>WT1</em>, or N- or K-RAS mutations. Complete remission was achieved in 57% of evaluable patients who had received intensive chemotherapy. In this group, <em>TET2</em&gt; mutations did not influence the complete remission rate or overall survival.}, number={7}, journal={Haematologica}, author={Olivier Kosmider and Eric Delabesse and Véronique Mansat-De Mas and Pascale Cornillet-Lefebvre and Odile Blanchet and Alain Delmer and Christian Recher and Sophie Raynaud and Didier Bouscary and Franck Viguié and Catherine Lacombe and Olivier A. Bernard and Norbert Ifrah and François Dreyfus and Michaëla Fontenay}, year={2011}, month={Jun.}, pages={1059-1063} }