@article{Maurizio Zangari_Shmuel Yaccoby_Lisa Pappas_Federica Cavallo_Naveen Sanath Kumar_Subramanian Ranganathan_Larry J. Suva_J. Michael Gruenwald_Steven Kern_Fenghuang Zhan_Dixie Esseltine_Guido Tricot_2011, place={Pavia, Italy}, title={A prospective evaluation of the biochemical, metabolic, hormonal and structural bone changes associated with bortezomib response in multiple myeloma patients}, volume={96}, url={https://haematologica.org/article/view/5885}, DOI={10.3324/haematol.2010.031302}, abstractNote={We prospectively evaluated the bone changes associated with proteasome inhibition using single agent bortezomib in relapsed or refractory myeloma patients. Ten patients received bortezomib 1.3 mg/m<sup>2</sup> per days 1, 4, 8 and 11 for three 21-day cycles, and 6 patients received 1 mg/m<sup>2</sup> per day with the same schedule. Bone architecture and metabolism changes were assessed by bone markers, micro-CT, bone histomorphometry, tetracycline labeling and serum parathormone levels. Bone parameter variations were compared by response to treatment. Microarchitectural changes were observed in all evaluable responsive patients. Bone alkaline phosphatase changes were associated with disease response (≥PR <em>vs</em>. others <em>P</em>=0.03 cycle 1, day 11) serum parathormone levels were also significantly increased (<em>P</em>=0.04 on days 11, 21, 33) in responding individuals.This study demonstrates that the myeloma control produced by proteasome inhibition is associated with bone changes and to a discrete pattern of hormonal variation. (<em>Clinicaltrials.gov identifier: <a class="external-ref external-ref-type-clintrialgov" href="/lookup/external-ref?link_type=CLINTRIALGOV&amp;access_num=NCT00569868&amp;atom=%2Fhaematol%2F96%2F2%2F333.atom">NCT00569868</a></em&gt;)}, number={2}, journal={Haematologica}, author={Maurizio Zangari and Shmuel Yaccoby and Lisa Pappas and Federica Cavallo and Naveen Sanath Kumar and Subramanian Ranganathan and Larry J. Suva and J. Michael Gruenwald and Steven Kern and Fenghuang Zhan and Dixie Esseltine and Guido Tricot}, year={2011}, month={Jan.}, pages={333-336} }