@article{Santiago Montes-Moreno_Ana-Rosa Gonzalez-Medina_Socorro-María Rodriguez-Pinilla_Lorena Maestre_Lydia Sanchez-Verde_Giovanna Roncador_Manuela Mollejo_Juan F. García_Javier Menarguez_Carlos Montalbán_M. Carmen Ruiz-Marcellan_Eulogio Conde_Miguel A. Piris_2010, place={Pavia, Italy}, title={Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotype}, volume={95}, url={https://haematologica.org/article/view/5688}, DOI={10.3324/haematol.2009.016113}, abstractNote={<strong>Background</strong> Plasmablastic lymphoma has recently come to be considered a distinct entity among mature B cell neoplasms, although the limits with diffuse large B-cell lymphoma (DLBCL) need to be more accurately defined.<strong>Design and Methods</strong> Here we show the results of an immunohistochemical study of 35 cases of plasmablastic lymphoma compared with a set of 111 conventional DLBCLs.<strong>Results</strong> Our results demonstrate that the use of a limited combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables the identification of a plasmablastic immunophenotype highly characteristic of plasmablastic lymphoma cases and associated with an aggressive clinical behavior. Additionally, the study shows that the acquisition of a partial plasmablastic phenotype (PRDM1/BLIMP1 expression) in DLBCL is associated with shorter survival in R-CHOP-treated patients.<strong>Conclusions</strong&gt; The use of a restricted combination of immunohistochemical markers (PAX5&CD20, PRDM1/BLIMP1 and XBP1s) enables a more accurate definition of terminal differentiation for large B-cell lymphoma.}, number={8}, journal={Haematologica}, author={Santiago Montes-Moreno and Ana-Rosa Gonzalez-Medina and Socorro-María Rodriguez-Pinilla and Lorena Maestre and Lydia Sanchez-Verde and Giovanna Roncador and Manuela Mollejo and Juan F. García and Javier Menarguez and Carlos Montalbán and M. Carmen Ruiz-Marcellan and Eulogio Conde and Miguel A. Piris}, year={2010}, month={Jul.}, pages={1342-1349} }