@article{Julie A. Britton_Aneire E. Khan_Sabine Rohrmann_Nikolaus Becker_Jakob Linseisen_Alexandra Nieters_Rudolf Kaaks_Anne Tjønneland_Jytte Halkjær_Marianne Tang Severinsen_Kim Overvad_Tobias Pischon_Heiner Boeing_Antonia Trichopoulou_Victoria Kalapothaki_Dimitrios Trichopoulos_Amalia Mattiello_Giovanna Tagliabue_Carlotta Sacerdote_Petra H.M. Peeters_H. Bas Bueno-de-Mesquita_Eva Ardanaz_Carmen Navarro_Paula Jakszyn_Jone M. Altzibar_Göran Hallmans_Beatrice Malmer_Göran Berglund_Jonas Manjer_Naomi Allen_Timothy Key_Sheila Bingham_Hervé Besson_Pietro Ferrari_Mazda Jenab_Paolo Boffetta_Paolo Vineis_Elio Riboli_2008, place={Pavia, Italy}, title={Anthropometric characteristics and non-Hodgkin’s lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)}, volume={93}, url={https://haematologica.org/article/view/5071}, DOI={10.3324/haematol.13078}, abstractNote={<strong>Background</strong> The incidences of non-Hodgkin’s lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin’s lymphoma and multiple myeloma.<strong>Design and Methods</strong> In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin’s lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin’s lymphoma and multiple myeloma in relation to the anthropometric characteristics.<strong>Results</strong> Height was associated with overall non-Hodgkin’s lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14–1.98) for highest versus lowest quartile; <em>p</em>-trend < 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin’s lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85–1.38) and 0.92 (95% CI 0.71–1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05–4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59–2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29–4.21) and heavier men (RR 1.77, 95% CI 1.02–3.05).<strong>Conclusions</strong&gt; The EPIC analyses support an association between height and overall non-Hodgkin’s lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin’s lymphoma subtypes.}, number={11}, journal={Haematologica}, author={Julie A. Britton and Aneire E. Khan and Sabine Rohrmann and Nikolaus Becker and Jakob Linseisen and Alexandra Nieters and Rudolf Kaaks and Anne Tjønneland and Jytte Halkjær and Marianne Tang Severinsen and Kim Overvad and Tobias Pischon and Heiner Boeing and Antonia Trichopoulou and Victoria Kalapothaki and Dimitrios Trichopoulos and Amalia Mattiello and Giovanna Tagliabue and Carlotta Sacerdote and Petra H.M. Peeters and H. Bas Bueno-de-Mesquita and Eva Ardanaz and Carmen Navarro and Paula Jakszyn and Jone M. Altzibar and Göran Hallmans and Beatrice Malmer and Göran Berglund and Jonas Manjer and Naomi Allen and Timothy Key and Sheila Bingham and Hervé Besson and Pietro Ferrari and Mazda Jenab and Paolo Boffetta and Paolo Vineis and Elio Riboli}, year={2008}, month={Oct.}, pages={1666-1677} }