@article{Huiling Shen_Wenlin Xu_Zhaoyang Wu_Huarong Tang_Yanyan Xie_Ximing Zhong_2007, place={Pavia, Italy}, title={Down-regulation of WT1/+17AA gene expression using RNAi and modulating leukemia cell chemotherapy resistance}, volume={92}, url={https://haematologica.org/article/view/4575}, DOI={10.3324/haematol.11010}, abstractNote={We have shown that inhibition of WT1/+17AA protein expression following transfection with a vector-based small interfering RNA expression construct in K562 cell lines, leads to a decrease in MDR1 and P-glycoprotein levels, accumulation of Rh123, and enhancement of the doxorubicin cytotoxicity. Our findings suggest that WT1/+17AA exerts its oncogenic function by modulating multidrug resistance in leukemia cells.}, number={9}, journal={Haematologica}, author={Huiling Shen and Wenlin Xu and Zhaoyang Wu and Huarong Tang and Yanyan Xie and Ximing Zhong}, year={2007}, month={Sep.}, pages={1270-1272} }