@article{I Tinhofer_M Steurer_G Leitinger_H Rumpold_A Egle_M Erdel_R Greil_2006, place={Pavia, Italy}, title={The effect of IgVH mutational status on the induction of apoptosis by rituximab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: evidence from a clinical phase I/II trial}, volume={91}, url={https://haematologica.org/article/view/4168}, DOI={10.3324/%x}, abstractNote={We investigated tumor cell apoptosis in vivo in 14 heavily pretreated patients with B-cell chronic lymphocytic leukemia undergoing rituximab monotherapy. Apoptosis induction was more pronounced in patients with mutated IgVH genes than in those with unmutated IgVH genes, independently of the levels of expression of CD20, CD38, and ZAP-70 and of the presence of 17p deletion. Our results suggest an association between IgVH gene mutational status and rituximab-induced apoptosis.}, number={9}, journal={Haematologica}, author={I Tinhofer and M Steurer and G Leitinger and H Rumpold and A Egle and M Erdel and R Greil}, year={2006}, month={Sep.}, pages={1291-1293} }