@article{E Laane_AR Derolf_E Bjorklund_J Mazur_H Everaus_S Soderhall_M Bjorkholm_A Porwit-MacDonald_2006, place={Pavia, Italy}, title={The effect of allogeneic stem cell transplantation on outcome in younger acute myeloid leukemia patients with minimal residual disease detected by flow cytometry at the end of post-remission chemotherapy}, volume={91}, url={https://haematologica.org/article/view/4014}, DOI={10.3324/%x}, abstractNote={Minimal residual disease (MRD) levels were determined by multi-parameter flow cytometry in 45 younger adult patients ( pound60 years old) with acute myeloid leukemia (AML) in complete remission. Data were collected after induction (MRD1; n=43) and/or at the end of post-remission chemotherapy or before stem cell transplantation (SCT)(MRD2; n=31). Patients with detectable MRD2 who underwent allogeneic or autologous SCT had significantly better 5-year relapse-free survival than patients not transplanted (80%, 53% and 0%, respectively p=0.003). Therefore allogeneic SCT should be considered in younger adult AML patients with detectable MRD at the end of post-remission chemotherapy. Autologous SCT may be an alternative for patients not eligible for allogeneic SCT.}, number={6}, journal={Haematologica}, author={E Laane and AR Derolf and E Bjorklund and J Mazur and H Everaus and S Soderhall and M Bjorkholm and A Porwit-MacDonald}, year={2006}, month={Jun.}, pages={833-836} }