@article{P Koistinen_S Ruuska_M Saily_S Kakko_P Siitonen_T Siitonen_MJ Savolainen_VL Kinnula_ER Savolainen_2006, place={Pavia, Italy}, title={An association between manganese superoxide dismutase polymorphism and outcome of chemotherapy in acute myeloid leukemia}, volume={91}, url={https://haematologica.org/article/view/4013}, DOI={10.3324/%x}, abstractNote={Manganese superoxide dismutase (MnSOD) protects cells against oxidative stress by eliminating superoxides. Hypothetically, decreased MnSOD levels in cancer might lead to increased oxidative stress and, thus, to increased sensitivity of cells to chemotherapy agents. Eighty-nine patients with acute myeloid leukemia (AML) were analyzed for a functional C to T polymorphism of MnSOD, which could potentially lead to decreased enzyme concentrations inside mitochondria. A significant survival advantage (p=0.02) was observed for those AML patients carrying T-containing alleles of MnSOD compared to the patients with the CC genotype. These preliminary results may indicate an important role for genetic factors regulating the cellular redox state in determining the outcome of leukemia chemotherapy.}, number={6}, journal={Haematologica}, author={P Koistinen and S Ruuska and M Saily and S Kakko and P Siitonen and T Siitonen and MJ Savolainen and VL Kinnula and ER Savolainen}, year={2006}, month={Jun.}, pages={829-832} }