@article{M Franchini_D Girelli_O Olivieri_C Bozzini_M Guiotto_G Zardini_G Lippi_F Manzato_G Gandin_2005, place={Pavia, Italy}, title={Clinical heterogeneity of acquired hemophilia A: a description of 4 cases}, volume={90}, url={https://haematologica.org/article/view/3465}, DOI={10.3324/%x}, abstractNote={Acquired hemophilia A is a rare but severe auto-immune bleeding disorder characterized by the presence of autoantibodies directed against clotting factor VIII. Acquired hemophilia A may be idiopathic or associated with several conditions, such as postpartum, autoimmune diseases, malignancies or drugs. The treatment modalities of bleeding episodes and eradication of the factor VIII auto-antibody depend on the titer of anti-factor VIII:C and may include desmopressin (DDAVP), prednisolone, prednisolone-cyclophosphamide, high dose intravenous gammaglobulin, FVIII-VWF concentrate and/or recombinant FVIIa (rFVIIa). In this study we report four cases of autoimmune factor VIII inhibitors (2 associated with autoimmune disorders, 2 idiopathic) demonstrating the heterogeneity of this disease from pathogenic, clinical, therapeutic and prognostic points of view.}, number={3}, journal={Haematologica}, author={M Franchini and D Girelli and O Olivieri and C Bozzini and M Guiotto and G Zardini and G Lippi and F Manzato and G Gandin}, year={2005}, month={Mar.}, pages={ECR16-ECR16} }