@article{Kayser_Martínez-Cuadrón_Rodriguez-Veiga_Hänel_Tormo_Schäfer-Eckart_Botella_Stölzel_del Castillo_Keller_Rodriguez-Medina_Held_Amigo_Schliemann_Colorado_Kaufmann_Garcia_Krause_Görner_Jost_Steffen_Zukunft_Platzbecker_Ho_Baldus_Serve_Müller-Tidow_Thiede_Bornhäuser_Montesinos_Röllig_Schlenk_2023, place={Pavia, Italy}, title={Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia}, volume={108}, url={https://haematologica.org/article/view/haematol.2022.282127}, DOI={10.3324/haematol.2022.282127}, abstractNote={<p>We retrospectively studied 97 acute myeloid leukemia patients with trisomy 19 (median age at diagnosis 57 years; range, 17- 83 years) treated between 2001 and 2019 within two multicenter study groups. Trisomy 19 occurred alone in ten (10.5%) patients, with additional abnormalities being present in non-complex karyotypes in eight (8%) patients and in complex karyotypes in 79 (82%) patients. Altogether, karyotypes characterized by trisomies only were present in 27 (28%) patients. Data on response and outcome of intensively treated patients were available for 92 cases. The median follow-up was 6.4 years (95% confidence interval [95% CI]: 2.9-9.0 years). The complete remission (CR) rate after induction therapy was 52% (48 patients); the early death rate was 10% (n=9). Notably, patients with trisomy 19 as the sole abnormality had a CR rate of 89%. Allogeneic hematopoietic stem cell transplantation (allo-HCT) was performed in 34 (35%) patients (CR, n=19; active disease, n=15). Five-year relapse-free and overall survival rates were 26% (95% CI: 16-43%) and 20% (95% CI: 13-31%), respectively. Overall survival rates were significantly higher in patients with trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only (P=0.05). An Andersen-Gill model including allo-HCT as a time-dependent covariable on overall survival revealed that trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only was a favorable factor (hazard ratio [HR]=0.47; P=0.021); higher age at diagnosis had an adverse impact (10 years difference; HR=1.29; P=0.002), whereas allo-HCT did not have a beneficial impact (odds ratio=1.45; P=0.21). In our cohort, patients with trisomy 19 as the sole abnormality or within karyotypes characterized by trisomies only had a high CR rate and better clinical outcome.</p&gt;}, number={8}, journal={Haematologica}, author={Kayser, Sabine and Martínez-Cuadrón, David and Rodriguez-Veiga, Rebeca and Hänel, Mathias and Tormo, Mar and Schäfer-Eckart, Kerstin and Botella, Carmen and Stölzel, Friedrich and del Castillo, Teresa Bernal and Keller, Ulrich and Rodriguez-Medina, Carlos and Held, Gerhard and Amigo, Maria-Luz and Schliemann, Christoph and Colorado, Mercedes and Kaufmann, Martin and Garcia, Manuel Barrios and Krause, Stefan W. and Görner, Martin and Jost, Edgar and Steffen, Björn and Zukunft, Sven and Platzbecker, Uwe and Ho, Anthony D. and Baldus, Claudia D. and Serve, Hubert and Müller-Tidow, Carsten and Thiede, Christian and Bornhäuser, Martin and Montesinos, Pau and Röllig, Christoph and Schlenk, Richard F.}, year={2023}, month={Aug.}, pages={2059-2066} }