@article{Mateos_Weisel_Martin_Berdeja_Jakubowiak_Stewart_Jagannath_Lin_Diels_Ghilotti_Thilakarathne_Perualila_Cabrieto_Haefliger_Erler-Yates_Hague_Jackson_Schecter_Strulev_Nesheiwat_Pacaud_Einsele_Moreau_2023, place={Pavia, Italy}, title={Adjusted comparison of outcomes between patients from CARTITUDE-1 <i>versus</i> multiple myeloma patients with prior exposure to proteasome inhibitors, immunomodulatory drugs and anti-CD38 antibody from the prospective, multinational LocoMMotion study of real-world clinical practice}, volume={108}, url={https://haematologica.org/article/view/haematol.2021.280482}, DOI={10.3324/haematol.2022.280482}, abstractNote={<p>Ciltacabtagene autoleucel (cilta-cel) is a chimeric antigen receptor T-cell therapy studied in patients with multiple myeloma exposed to three classes of treatment in the single-arm CARTITUDE-1 study. To assess the effectiveness of cilta-cel compared to real-world clinical practice (RWCP), we performed adjusted comparisons using individual patients’ data from CARTITUDE-1 and LocoMMotion, a prospective, multinational study of patients with multiple myeloma triple-class exposed of treatment. Comparisons were performed using inverse probability weighting. In CARTITUDE-1, 113 patients were enrolled, and 97 patients were infused with cilta-cel. In LocoMMotion, 248 patients were enrolled, and 170 patients were included in the comparisons versus infused patients. Ninety-two unique regimens were used in LocoMMotion, most frequently carfilzomib-dexamethasone (13.7%), pomalidomide-cyclophosphamide-dexamethasone (13.3%) and pomalidomidedexamethasone (11.3%). Adjusted comparisons showed that patients treated with cilta-cel were 3.12-fold more likely to respond to treatment than those managed by RWCP (response rate, 3.12, 95% confidence interval [95% CI]: 2.24-4.00), had their risk of progression or death reduced to by 85% (progression-free survival hazard ratio=0.15, 95% CI: 0.08-0.29), and a risk of death lowered by 80% (overall survival hazard ratio HR=0.20, 95% CI: 0.09-0.41). The incremental improvement in healthrelated quality of life from baseline for cilta-cel versus RWCP at week 52, as measured by EORTC QLQ-C30 Global Health Status, was 13.4 (95% CI: 3.5-23.6) and increased to 30.8 (95% CI: 21.8-39.8) when including death as additional information regarding patients’ health status. Patients treated with cilta-cel experienced more adverse events than those managed with RWCP (any grade: 100% vs. 83.5%). The results from this study demonstrate improved efficacy outcomes of cilta-cel versus RWCP and highlight its potential as a novel and effective treatment option for patients with multiple myeloma triple-class exposed of antimyeloma treatment. CARTITUDE-1 is registered with clinicaltrials gov. Identifier: NCT03548207. LocoMMotion is registered with clinicaltrials gov. Identifier: NCT04035226.</p&gt;}, number={8}, journal={Haematologica}, author={Mateos, Maria-Victoria and Weisel, Katja and Martin, Thomas and Berdeja, Jesús G. and Jakubowiak, Andrzej and Stewart, A. Keith and Jagannath, Sundar and Lin, Yi and Diels, Joris and Ghilotti, Francesca and Thilakarathne, Pushpike and Perualila, Nolen J. and Cabrieto, Jedelyn and Haefliger, Benjamin and Erler-Yates, Nichola and Hague, Clare and Jackson, Carolyn C. and Schecter, Jordan M. and Strulev, Vadim and Nesheiwat, Tonia and Pacaud, Lida and Einsele, Hermann and Moreau, Philippe}, year={2023}, month={Aug.}, pages={2192-2204} }