@article{Petrone_Gaulin_Derkach_Kishtagari_Robson_Parameswaran_Stein_2023, place={Pavia, Italy}, title={Routine clinical parameters and laboratory testing predict therapy-related myeloid neoplasms after treatment for breast cancer}, volume={108}, url={https://haematologica.org/article/view/haematol.2021.280437}, DOI={10.3324/haematol.2021.280437}, abstractNote={<p>We aim to identify predictors of therapy-related myeloid neoplasms (t-MN) in patients with breast cancer (BC) and cytopenias to determine the timing of bone marrow biopsy (BMBx). Patients with BC and cytopenias who were referred for BMBx between 2002-2018 were identified using the Memorial Sloan Kettering Cancer Center institutional database. Characteristics associated with the risk of t-MN were evaluated by multivariable logistic regression and included in a predictive model. The average area under the receiver operating characteristic curve (AUC) was estimated by 5-fold cross-validation. Of the 206 BC patients who underwent BMBx included in our study, 107 had t-MN. By multivariable analysis, white blood cell count 4-11 K/mcL, absolute neutrophil count (ANC) ≥1.5 K/mcL, hemoglobin ≥12.2 g/dL, red cell distribution width 11.5-14.5%, the presence of bone metastasis and a time from BC diagnosis to BMBx &lt;15 months significantly decreased the likelihood of t-MN. The average AUC was 0.88. We stratified our cohort by bone metastasis and by findings on peripheral smear. In both the subset without bone metastasis (n=159) and in the cohort with no blasts or dysplastic cells on peripheral smear (n=96) our variables had similar effects on the risk of t-MN. Among the 47 patients with bone metastasis, an ANC ≥1.5 K/mcL was the only variable associated with a decreased risk of t-MN. Our findings show that in patients with BC and unexplained cytopenias, clinical and laboratory parameters can predict t-MN and assist clinicians in determining the timing of a BMBx.</p&gt;}, number={1}, journal={Haematologica}, author={Petrone, Giulia and Gaulin, Charles and Derkach, Andriy and Kishtagari, Ashwin and Robson, Mark E. and Parameswaran, Rekha and Stein, Eytan M.}, year={2023}, month={Jan.}, pages={161-170} }